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Their cognitive function was assessed, measuring memory, attention, spatial cognition, and language. Some (113) of the participants also underwent PET brain scans, measuring deposits of tau and amyloid, two proteins which cause the most common type of dementia, Alzheimer's disease, when they build up in the brain.
研究人员评估了他们的认知能力，测试了记忆力、注意力、空间认知力和语言能力。一些参与者（113人）还接受了PET脑部扫描，测量了陶蛋白和淀粉样蛋白的沉积物，当这两种蛋白质在大脑内堆积时，会引发最常见的痴呆症——阿兹海默症。
The researchers found that people who exhibited higher RNT patterns experienced more cognitive decline over a four-year period, and declines in memory (which is among the earlier signs of Alzheimer's disease), and they were more likely to have amyloid and tau deposits in their brain.
研究人员发现，展示出更高水平反复性消极思维模式的人在四年内经历了更严重的认知衰退和记忆力下降（阿兹海默症的早期征兆之一），这些人的大脑中也更可能有陶蛋白和淀粉样蛋白的沉积物。
Depression and anxiety were associated with subsequent cognitive decline but not with either amyloid or tau deposition, suggesting that RNT could be the main reason why depression and anxiety contribute to Alzheimer's disease risk.
抑郁症和焦虑症与日后的认知能力下降有关，但与陶蛋白和淀粉样蛋白的沉积物无关，这表明反复性消极思维可能是抑郁症和焦虑症引起阿兹海默症风险升高的主要原因。
"We propose that repetitive negative thinking may be a new risk factor for dementia as it could contribute to dementia in a unique way," said Dr Marchant.
马钱特说：“我们认为，反复性消极思维可能是痴呆症的一个新的风险因素，因为它可能会以一种独特的方式引发痴呆症。”
The researchers suggest that RNT may contribute to Alzheimer's risk via its impact on indicators of stress such as high blood pressure, as other studies have found that physiological stress can contribute to amyloid and tau deposition.
研究人员指出，反复性消极思维可能会通过影响高血压等压力指标来提高患阿兹海默症的风险。其他研究已经发现，生理压力会导致陶蛋白和淀粉样蛋白的沉积。
Co-author Dr Gael Chételat commented: "Our thoughts can have a biological impact on our physical health, which might be positive or negative. Mental training practices such as meditation might help promoting positive- while down-regulating negative-associated mental schemes.
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